“The problems of disease are more... William Osler, 1921

“The problems of disease are more complicated and difficult than any others with which the trained mind has to grapple...Variability is the law of life. As no two faces are the same, so no two bodies are alike, and no two individuals react alike and behave alike under the abnormal conditions which we know as disease. This is the fundamental difficulty in the education of the physician, and one which he or she may never grasp...”Probability is the guide of life.”